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Sterilization principle of isothiazolinone

Posted on August 17, 2023 By admin No Comments on Sterilization principle of isothiazolinone

Isothiazolinone is a broad-spectrum fungicide, which involves interfering with the cell wall synthesis of pathogens and interfering with their cell membrane function. The following are the main principles of isothiazolinone sterilization:

Inhibition of cell wall synthesis: Isothiazolinone can inhibit cell wall synthesis in bacteria and fungi. The cell walls of bacteria and fungi are crucial for their survival and proliferation. Isothiazolinone inhibits key enzymes in cell wall synthesis, such as β- The activity of 1,3-glucan synthase and other enzymes hinders the synthesis and repair of cell walls, leading to the fragility, thinning, and even rupture of pathogen cell walls, ultimately leading to cell death.

Interference with cell membrane function: Isothiazolinone can also interfere with the cell membrane function of bacteria and fungi. The cell membranes of bacteria and fungi play an important role in controlling the entry and exit of substances and maintaining intracellular stability. Isothiazolinone can interact with lipid molecules in the cell membrane, disrupting the integrity and stability of the cell membrane. This can lead to the leakage of substances inside and outside the cells and the disturbance of ion balance, thereby interfering with the physiological activities and cell metabolism of pathogens, ultimately leading to cell death.

It should be noted that isothiazolinone is a chemically synthesized fungicide, and its use should follow the product instructions and relevant safety operating procedures. For specific application and mechanism details, it is recommended to refer to relevant research literature or consult professionals.

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